Publications

Research literature

1. 2026 Frontiers in Immunology

   Proteomic profiling of single extracellular vesicles reveals association of CD31+ EV subpopulation with immune dysregulation in people living with HIV

   Authors

   Ning Ding, Jiewei Sun, Aiwei Zhu, Jiajun Li, Jin Sun, Hongxia Yan, Yuanyuan Ma, Xiangchuan He, Tong Zhang, Qi Yao, Bin Su

   Research field

   Immune, Infection

   Sample type

   Plasma

   View paper

2. 2026 Chemical Engineering Journal

   Proteomics-guided multivalent capture and integrated amplification enable profiling of tumor-derived extracellular vesicles in gastric cancer

   Authors

   Ke Ge, Yongan Ren, Pengcheng Wang, Guangzhong Ma, Bo Yao, Changku Jia, Yuanyu Wang, Kai Ye

   Research field

   Oncology

   Sample type

   tumor-derived EVs

   View paper

3. 2026 Extracellular Vesicles and Circulating Nucleic Acids

   Dynamic profiles and subpopulation characteristics of extracellular vesicles in patients undergoing transcatheter pulmonary valve replacement

   Authors

   Runzhang Liang, Jiaxiong Wu, Naijimuding Abudurexiti, Jing Ling, Zirui Peng, Canxin Wang, Jinxin Li, Yong Zhang, Haiyun Yuan, Shusheng Wen

   Research field

   Cardiovascular

   Sample type

   Plasma

   View paper

4. 2026 Signal Transduction and Targeted Therapy

   An integrated multiomic single-vesicle atlas delineates graft exosome heterogeneity in chronic lung allograft dysfunction

   Authors

   Dong Tian, Xiangyun Zheng, Zengwei Yu, Dapeng Wang, Weiyang Chen, Yaling Liu, Zehui Liu, Boyang Xia, Xiaohan Jin, Haoji Yan, Ye Wu, Yongsheng Zhao, Chuanfen Zhang, Qiang Pu, Jingyu Chen, Masaaki Sato & Lunxu Liu

   Research field

   Respiratory Medicine

   Sample type

   Lung graft tissue-derived EVs, Plasma

   View paper

5. 2026 BMC Medicine

   Surface protein dynamics of neuron-derived extracellular vesicles track electroconvulsive therapy response in schizophrenia

   Authors

   Yan Li, Yu Wang, Chenying Jiang, Yuanhao Li, Qi Yan, Xinyu Fang, Shuyan Tong, Chaoran Wu, Shaotong Zhang, Chao Zhou, Xuan Ge, Meilin Liao, Peijuan Wang & Xiangrong Zhang

   Research field

   Neurology

   Sample type

   Plasma

   View paper

6. 2026 Human Cell

   Extracellular vesicle-derived CDCP1 promotes chemoresistance and macrophage polarization in breast cancer

   Authors

   Yibing Liu, Li Ma, Ting Zhu, Di Wu, Yonglei Liu

   Research field

   Oncology

   Sample type

   tissue-derived EVs

   View paper

7. 2026 Extracellular Vesicles and Circulating Nucleic Acids

   Verification of the predictive value of EV-associated biomarkers MMP9 and CEACAM1 in rehabilitation of ischemic stroke

   Authors

   Jiao Luo, You Cai, Yanling Cai, Chunxia Zhang, Ankang Liu, Yongyang Huo, Xuehui Fan, Ruixue Ye, Hong Gao, Meiling Huang, Xiaohua Zhang, Mingchao Zhou, Yulong Wang

   Research field

   Ischemic stroke, Neurology

   Sample type

   Serum

   View paper

8. 2026 Journal of Nanobiotechnology

   DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction

   Authors

   Nan Liu, Guoyue Wei, Haoran Wang, Yameng Zhang, Xipeng Sun, Fengling Lai, Yan Zheng, Keqing Hu, Tao Xu, Guohai Su, Rong Huang & Lingjun Tong

   Research field

   Cardiovascular

   Sample type

   Cell line, Plasma

   View paper

9. 2026 Burns

   Human umbilical cord mesenchymal stem cell-derived small extracellular vesicles accelerate diabetic wound healing by reprogramming fibroblast subpopulations and delivering pro-regenerative cargos

   Authors

   Caixiang Chen, Hangqi Gao, Xintian Zhang, Yu Fu, Siqin Yang, Guohua Wu, Jiansheng Zheng, Penghong Chen, Zhaohong Chen

   Research field

   Regenerative Medicine

   Sample type

   hUC-MSC-sEVs

   View paper

10. 2026 Journal of Extracellular Vesicles

    Endothelium-Treg Communication Through Extracellular Vesicle Transfer Exacerbates Acute Respiratory Distress Syndrome

    Authors

    Xu Liu, Wei Huang, Xiwen Zhang, Shiming Li, Haofei Wang, Zongsheng Wu, Shuangfeng Zi, Lu Wang, Ling Liu, Yi Yang, Jianfeng Xie, Mingzhu Zheng, Jie Chao, Haibo Qiu

    Research field

    Respiratory Medicine

    Sample type

    BALF

    View paper

11. 2026 npj precision oncology

    Proteomic profiling of single extracellular vesicles as a promising new approach for the diagnosis and treatment modality of advanced ovarian cancer

    Authors

    Beier Wu, XupingYang, Yanling Cai, ShihanWan, JingfangLiu, Jie Xing, XinChen, JiejieZhang, Yanlu Jin, Aijun Yu &LiYang

    Research field

    Oncology

    Sample type

    Plasma

    View paper

12. 2025 View

    Single particle protein profiling for high myopic cataract lens capsule tissue-derived extracellular vesicles reveals macrophage involvement and AQP1 correlation

    Authors

    Yun Su, Xinrui Wu, Wanzhuo He, Chenxi Yan, Yu Wu, Li Fang, Tao Guo, Xianqun Fan

    Research field

    EV biology

    Sample type

    tissue-derived EVs

    View paper

13. 2025 Journal of Inflammation Research

    Integrating Extracellular Vesicles Proteomics and Clinical Parameters to Develop a High-Precision Predictive Model for Severe Asthma

    Authors

    Yuhao Qian, Fang Wang, Jiameng Gao, Zhilong Jiang, Xiwen Gao, Zhihong Chen

    Research field

    Respiratory Medicine

    Sample type

    Plasma

    View paper

14. 2025 Nature Communications

    Autophagic extracellular vesicles (AEVs) are distinct from exosomes and play crucial roles in viral infections

    Authors

    Kedan Mao, Fangfang Huo, Hongqi Wei, Furong Wang, Sidong Xiong & Yuxuan Fu

    Research field

    EV biology

    Sample type

    Cell line

    View paper

15. 2025 Extracellular Vesicles and Circulating Nucleic Acids

    A single-sEV analysis identifies plasma EPCAM+sEVs as a biomarker for early diagnosis and monitoring postoperative remission of thyroid cancer

    Authors

    Simin Yu, Yuting Luo, Tianfeng Dang, Congli Peng, Qing Gan, Yuxuan Liang, Jieqing Yu, Ping Long, Wensheng Zhou, Daofeng Dai

    Research field

    Oncology

    Sample type

    Plasma

    View paper

16. 2025 Nucleic Acids Research

    SVAtlas: a comprehensive single extracellular vesicle omics resource

    Authors

    Zhonghui Wei , Na Zhou , Ming Jing , Yanling Cai , Yingxin Zhang , Xinyu Wang , Linxinyu Wang , Di Wu , Fuzhong Xue , Qingzhen Hou

    Research field

    Database, Methods

    Sample type

    Database

    View paper

17. 2025 Nature Communications

    Single urinary extracellular vesicle proteomics identifies complement receptor CD35 as a biomarker for sepsis-associated acute kidney injury

    Authors

    Ning Li, Tao-Tao Tang, Menglei Gu, Yu-Qi Fu, Wei-Wei Qian, Nan Nan Ma, An-Ran Shen, Tingting Zhu, Run-Bo Huo, Tao Zhang, Jian-Feng Xie, Lu Zhang, Bi-Cheng Liu, Lin-Li Lv

    Research field

    Nephrology

    Sample type

    Urine

    View paper

18. 2025 Journal of Extracellular Biology

    Systematic Evaluation of Isolation Techniques and Freeze-Thaw Effects on Plasma Extracellular Vesicle Heterogeneity and Subpopulation Profiling

    Authors

    Xueqi Li, Xiangyu Li, Lingjun Tong, Liqiao Hu, Yanfen Hong, Ruoyu Zhou, Zonghong Li, Ming Dong, Junjie Hou, Tao Xu, Wen Zhong

    Research field

    Methods

    Sample type

    Plasma

    View paper

19. 2025 The Journal of Heart and Lung Transplantation

    Integrated Multi-Omic Single-Vesicle Atlas Reveal the Diversity and Pathophysiological Effect of Graft-Derived Exosomes in Chronic Lung Allograft Dysfunction Rat Model

    Authors

    D. Tian, X. Zheng, Z. Yu, S. Hou, Y. Wu, M. Sato, L. Liu

    Research field

    Respiratory Medicine, Transplantation

    Sample type

    Tissue

    View paper

20. 2025 International Journal of General Medicine

    The Identification of FN1 as an Early Diagnostic Marker for Recurrent Abortion by Single-Exosome Profiling

    Authors

    Chenlu Wang, Zhaojin Lu, Guangpeng She, Kaining Chen, Huazhong Zhou, Xueli Zhan, Hongyan Yu, Lei Pi, Liandong Zuo, Di Che

    Research field

    Reproductive Medicine

    Sample type

    Serum

    View paper

21. 2024 Cell Communication and Signaling

    Adipose tissue protects against skin photodamage through CD151- and AdipoQ-EVs

    Authors

    Yan-Wen Wang, Poh-Ching Tan, Qing-Feng Li, Xue-Wen Xu, Shuang-Bai Zhou

    Research field

    Dermatology

    Sample type

    Tissue

    View paper

22. 2024 Schizophrenia

    Profiling expressing features of surface proteins on single-exosome in first-episode Schizophrenia patients: a preliminary study

    Authors

    Sijie Zhang, Aijun Liao, Yujue Wang, Qian Liu, Lijun Ouyang, Huiqing Peng, Liu Yuan, Linlin Zhao, Xinbo Yang, Xiaogang Chen, Ying He, Zongchang Li

    Research field

    Neurology

    Sample type

    Plasma

    View paper

23. 2024 Translational Oncology

    Plasma extracellular vesicles proteomics in meningioma patients

    Authors

    Yiqiang Zhou, Yanxin Lu, Xiaolong Wu, Jie Bai, Xupeng Yue, Yifei Liu, Yanling Cai, Xinru Xiao

    Research field

    Oncology

    Sample type

    Plasma

    View paper

24. 2024 Scientific Reports

    Macrophage-derived CD36+exosome subpopulations as novel biomarkers of Candida albicans infection

    Authors

    Shuo Li, Yanyan Xv, Yuanyuan Sun, Ziyi Shen, Ruiying Hao, Jingjing Yan, Mengru Liu, Zhao Liu, Tingting Jing, Xiaojing Li, Xiujuan Zhang

    Research field

    Immune, Infection

    Sample type

    Cell line

    View paper

25. 2024 Journal of Nanobiotechnology

    Single-sEV profiling identifies the TACSTD2+sEV subpopulation as a factor of tumor susceptibility in the elderly

    Authors

    Nannan Ning, Jianying Lu, Qianpeng Li, Mengmeng Li, Yanling Cai, Hongchun Wang, Jingxin Li

    Research field

    Aging, Oncology

    Sample type

    Serum

    View paper

26. 2024 Journal of Extracellular Vesicles

    Surface protein profiling and subtyping of extracellular vesicles in body fluids reveals non-CSF biomarkers of Alzheimer’s disease

    Authors

    You Cai, Ting Chen, Yanling Cai, Jiabang Liu, Bin Yu, Yixian Fan, Jun Su, Yixuan Zeng, Xiaohua Xiao, Lijie Ren, Yizhe Tang

    Research field

    Neurology

    Sample type

    EIS, MIS, NIS, Plasma, Serum, Urine

    View paper

27. 2024 Life (Basel)

    Extracellular Vesicles as Next-Generation Biomarkers in Lung Cancer Patients: A Case Report on Adenocarcinoma and Squamous Cell Carcinoma

    Authors

    Monika Ruzycka-Ayoush, Monika Prochorec-Sobieszek, Andrzej Cieszanowski, Maciej Glogowski, Anna Szumera-Cieckiewicz, Joanna Podgorska, Alicja Targonska, Kamil Sobczak, Grazyna Mosieniak, Ireneusz P Grudzinski

    Research field

    Oncology

    Sample type

    Tissue

    View paper

28. 2024 Molecular Oncology

    Single extracellular vesicle surface protein-based blood assay identifies potential biomarkers for detection and screening of five cancers

    Authors

    Yuxin Min, Wenjiang Deng, Huangbo Yuan, Dongliang Zhu, Renjia Zhao, Pengyan Zhang, Jiangli Xue, Ziyu Yuan, Tiejun Zhang, Yanfeng Jiang, Kelin Xu, Di Wu, Yanling Cai, Chen Suo, Xingdong Chen

    Research field

    Oncology

    Sample type

    Plasma

    View paper

29. 2023 Frontiers in Oncology

    Ascites-derived CDCP1+ extracellular vesicles subcluster as a novel biomarker and therapeutic target for ovarian cancer

    Authors

    Lingnan Kong, Famei Xu, Yukuan Yao, Zhihui Gao, Peng Tian, Shichao Zhuang, Di Wu, Tangyue Li, Yanling Cai, Jing Li

    Research field

    Oncology

    Sample type

    Ascites

    View paper

30. 2023 Frontiers in Immunology

    Proteomic profiling of single extracellular vesicles reveals colocalization of SARS-CoV-2 with a CD81/integrin-rich EV subpopulation in sputum from COVID-19 severe patients

    Authors

    Ruiting Sun, Yanling Cai, Yumin Zhou, Ge Bai, Airu Zhu, Panyue Kong, Jing Sun, Yimin Li, Yuefei Liu, Wenting Liao, Jiye Liu, Nan Cui, Jinsheng Xiang, Bing Li, Jincun Zhao, Di Wu, Pixin Ran

    Research field

    Immune, Infection

    Sample type

    Sputum

    View paper

31. 2023 Research

    Single-Exosome Profiling Identifies ITGB3+ and ITGAM+ Exosome Subpopulations as Promising Early Diagnostic Biomarkers and Therapeutic Targets for Colorectal Cancer

    Authors

    Wei Guo, Yanling Cai, Xianming Liu, Yuge Ji, Cuiyu Zhang, Liyan Wang, Wenting Liao, Yuefei Liu, Nan Cui, Jinsheng Xiang, Zesong Li, Di Wu, Jingxin Li

    Research field

    Oncology

    Sample type

    Plasma

    View paper

32. 2022 Extracellular Vesicle

    Cell-derived nanovesicles prepared by membrane extrusion are good substitutes for natural extracellular vesicles

    Authors

    Yi Wen, Qin Fu, Ashley Soliwoda, Sheng Zhang, Mingfeng Zheng, Wenjun Mao, Yuan Wan

    Research field

    Methods

    Sample type

    Cell line

    View paper

33. 2022 Human Molecular Genetics

    Genetic and phenotypic links between obesity and extracellular vesicles

    Authors

    Ranran Zhai, Lu Pan, Zhijian Yang, Ting Li, Zheng Ning, Yudi Pawitan, James F Wilson, Di Wu, Xia Shen

    Research field

    Metabolism

    Sample type

    Plasma

    View paper

34. 2021 ACS Omega

    Combined Analysis of Surface Protein Profile and microRNA Expression Profile of Exosomes Derived from Brain Microvascular Endothelial Cells in Early Cerebral Ischemia

    Authors

    Dexin Yang, Zongyang Li, Guoqing Gao, Xiaofeng Li, Zijun Liao, Yachao Wang, Weiping Li, Yuan Zhang, Wenlan Liu

    Research field

    Neurology

    Sample type

    Cell line

    View paper

35. 2019 Nature Communications

    Profiling surface proteins on individual exosomes using a proximity barcoding assay

    Authors

    Di Wu, Junhong Yan, Xia Shen, Yu Sun, Måns Thulin, Yanling Cai, Lotta Wik, Qiujin Shen, Johan Oelrich, Xiaoyan Qian, K. Louise Dubois, K. Göran Ronquist, Mats Nilsson, Ulf Landegren, Masood Kamali-Moghaddam

    Research field

    Methods

    Sample type

    Cell culture supernatants, Seminal fluid, Serum

    View paper